What Causes Parkinson’s Disease? Symptoms & Genetic Factors

Saima

Saima Afzal

1 October, 2025

What Causes Parkinson’s Disease? Symptoms & Genetic Factors

30-Second Summary:

  • Parkinson’s is a progressive brain disorder that affects movement, caused by the loss of dopamine-producing neurons.
  • Its exact cause is unknown, but age, genetics, and environmental factors all play a role.
  • Early signs include tremors, stiffness, slow movement, as well as non-motor symptoms like loss of smell, sleep issues, and mood changes.
  • True home care provides essential support for both motor and non-motor symptoms, enhancing safety and quality of life.

Parkinson’s disease affects millions, yet its causes and early signs are often misunderstood. It’s a progressive disorder that begins subtly, perhaps with a slight hand tremor, muscle stiffness, or a change in posture. 

As a CQC-registered, family-run provider, we specialise in supporting families through the challenges of Parkinson’s Care at Home, ensuring comfort and safety in familiar surroundings.

In this guide, we’ll explain what causes parkinson’s disease, the early symptoms, potential causes, and how professional, compassionate care can make a difference in daily life.

What Is Parkinson’s Disease?

Parkinson’s disease is a neurodegenerative disorder that primarily affects movement. It occurs when nerve cells (neurons) in the brain that produce dopamine become impaired or die.

Without sufficient dopamine, the brain cannot properly transmit signals to control movement, leading to the characteristic motor symptoms. Recognizing Parkinson’s disease symptoms early can help manage the condition more effectively.

In simple terms, Parkinson’s disease is a condition where certain brain cells gradually die, leading to movement and coordination problems.

Who Is at Risk?

Parkinson’s typically affects people over 60, with men having a slightly higher risk than women. While rare, early-onset Parkinson’s can occur in adults in their 20s or 30s, especially when there is a family history of the disease.

Understanding the early signs of Parkinson’s in females is equally important, as symptoms may develop differently and be misattributed to stress or menopause-related changes.

How Common Is Parkinson’s?

It is the second most common neurodegenerative disorder after Alzheimer’s disease. Globally, it’s estimated that about 1 in every 100 individuals over age 60 lives with Parkinson’s.

What Causes Parkinson’s Disease?

Researchers have identified multiple causes of Parkinson’s disease, including mitochondrial dysfunction and protein clumping in neurons.

The combination of age, genetics, and environmental factors is the most recognized cause of Parkinson’s disease.

Parkinson’s disease causes changes in the Brain, like:

  • Dopamine and Norepinephrine Loss: The primary cause of Parkinson’s disease is believed to be the gradual death of dopamine-producing neurons.The loss of norepinephrine contributes to non-motor symptoms, like fatigue and dizziness.
  • Lewy Bodies: A key hallmark of Parkinson’s is the presence of Lewy bodies, clumps of protein in brain cells. The primary protein found in these clumps is alpha-synuclein, which becomes misfolded and sticky, disrupting normal cell function.
  • Mitochondrial Dysfunction: Problems with mitochondria, the energy powerhouses of cells, can lead to cell damage and are believed to be another reason neurons start to die.

Several causes of Parkinson’s have been identified, including age, genetic predisposition, and environmental exposure.

  • Age: The single greatest risk factor; most people develop it after 60.
  • Genetics: Having a close relative with Parkinson’s increases risk, and specific genetic mutations are linked to a small percentage of cases.
  • Environmental Exposure: Prolonged exposure to herbicides, pesticides, or heavy metals may increase risk.
  • Head Injuries: Repeated head trauma has been linked to a higher risk of developing the disease.

What are the Early Symptoms of Parkinson’s Disease?

As Parkinson’s disease stages progress, symptoms become more pronounced and are categorized as motor and non-motor.

Early signs of Parkinson’s disease include:

  • A slight tremor in a hand or fingers (often at rest)
  • Slower movement (bradykinesia)
  • Smaller, more cramped handwriting (micrographia)
  • Softer or more monotone voice
  • Loss of smell (anosmia)
  • Trouble sleeping, including acting out dreams
  • Constipation
  • Mood changes like anxiety or depression

These non-motor signs can appear years before more obvious movement issues.

What are Motor and Non-Motor Parkinson’s Disease Symptoms?

As Parkinson’s disease stages advance, symptoms of Parkinson’s become more pronounced and are categorized as motor (movement-related) and non-motor.

Understanding the stages of Parkinson’s disease helps families plan effective care strategies.

Parkinson’s Disease Motor Symptoms:

  • Tremors (especially at rest)
  • Muscle rigidity or stiffness
  • Slow movement (bradykinesia)
  • Impaired balance and coordination (postural instability)
  • Shuffling walk or gait changes

Parkinson’s Disease Non-Motor Symptoms:

  • Sleep disturbances and fatigue
  • Cognitive changes, including memory and thinking issues
  • Depression, anxiety, and apathy
  • Constipation and bladder problems
  • Dizziness upon standing (due to blood pressure changes)

Is Parkinson’s Disease Genetic?

Parkinson’s disease is mostly not inherited, but about 10–15% of cases have a genetic link. Specific gene mutations can increase the risk, especially in early-onset cases. Most people develop it due to a mix of genetics and environmental factors.

Can Parkinson’s Be Prevented? Lifestyle and Risk Reduction

There is no proven way to completely prevent Parkinson’s. Research suggests that certain lifestyle habits and Parkinson’s disease self-care strategies, such as regular exercise, a healthy diet, and mental stimulation, may help reduce risk or slow progression

Strategies to prevent Parkinson’s disease include:

  • Regular Exercise: Improves brain health, mobility, and may have a protective effect on neurons.
  • Healthy Diet: A Mediterranean diet rich in antioxidants, fruits, vegetables, and omega-3 fatty acids may support brain health.
  • Avoiding Toxins: Limiting exposure to pesticides, herbicides, and other industrial chemicals.
  • Protecting Your Brain: Wearing helmets during sports and taking precautions to prevent head injuries.
  • Mental Stimulation: Keeping your brain active through learning, puzzles, and social engagement.

How Professional Home Care Helps Manage Parkinson’s Symptoms?

Managing Parkinson’s requires a holistic approach that goes hand in hand with medical Parkinson’s disease treatment, which addresses challenges, much like other forms of home care for elderly individuals who need daily assistance with mobility, medication, and well-being.

As a preferred provider on the Ethical Framework by Stockport Council, True Homecare’s trained caregivers offer specialised support tailored to the unique needs of each individual.

Alongside medical intervention, Parkinson’s disease treatment can include therapy, exercise, and professional home care.

Support with Motor Symptoms: 

Our caregivers provide essential support for mobility challenges. This includes assistance with standing and walking to reduce fall risk. 

It helps with daily tasks like eating and dressing that become difficult due to tremors or rigidity, and ensures a safe,clutter-free home environment. 

We also support prescribed exercise routines to maintain mobility.

Support with Non-Motor Symptoms:

Parkinson’s affects more than just movement. Our caregivers provide compassionate companionship and reliable medication reminders as part of broader Long Term Condition Support, helping individuals manage both the motor and non-motor aspects of the disease.

They support routines that improve sleep quality. We also assist with nutrition to help manage issues like constipation.

FAQs

Q: What are the early signs of Parkinson’s disease?

A: Early signs can include a slight tremor at rest, slowed movement, smaller handwriting, loss of smell, and changes in sleep or mood.

Q: Is Parkinson’s fatal?

A: No, Parkinson’s itself is not fatal; however, complications from the disease can be serious. Although progression varies widely, understanding Parkinson’s life expectancy helps families plan care with realistic expectations.

Q: Can Parkinson’s be cured?

A: Unfortunately, there is no cure yet. However, its symptoms can be effectively managed for many years with medications, therapy, and lifestyle support.

Q: How does Parkinson’s progress?

A: Parkinson’s is a progressive disease, meaning symptoms gradually worsen over time. Many people wonder how long you can live with Parkinson’s, but the truth is that outcomes depend on age, overall health, and access to proper care.

Saima Afzal